The Effect of Salvia Consumption on Serum Levels of Caspase-3 Following One Session Downhill Running

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of Physical Education and Sport Sciences, Islamic Azad University, Marivan Branch, Marivan, Iran.

2 department of physical education and sport sciences, Marivan branch, Islamic Azad University, Marivan, Iran

Abstract

Aim: The purpose of this study was to investigate the effect of Salvia officinalis extract on the serum levels of caspase 3 after a downhill running session.

Method: 12 healthy men (age: 24.38±2.75, weight: 75.57±5.48, BMI: 24.69±1.70) were randomly assigned to two groups of sage supplement and placebo in a crossover manner. Subjects consumed 100 mg capsules of sage extract (two per day) or placebo for two weeks. After 2 weeks, they performed one session of exercise on a treadmill with a negative slope on one day. The exercise protocol included one session of exercise with a negative slope of 12% at an intensity of 70% of maximum heart rate until voluntary fatigue (the average voluntary fatigue of the subjects was 30 minutes). Blood sampling was performed in two stages before and immediately after the exercise session.

Results: There was no significant difference in serum caspase 3 levels between the supplement group and the placebo group in the pre-test (p=0.134). The results of the Bonferroni post-hoc test showed that in the supplement group, the changes in caspase levels in the post-test compared to the pre-test were not statistically significant (p=0.650). In the placebo group, the levels of caspase 3 in the post-test compared to the pre-test were significantly higher (p=0.01).

Conclusion: The running downhill as eccentric contractions may lead to cell apoptosis through increasing caspase 3 levels, but short-term consumption of Salvia officinalis supplement is likely to inhibit exercise-induced cell death.

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Publisher: University of Kurdistan         Copyright © The Authors

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

 

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Research in Exercise Nutrition
Volume 3, Issue 1
April 2024
Pages 46-37

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History

  • Receive Date: 07 January 2025
  • Revise Date: 25 January 2025
  • Accept Date: 04 February 2025
  • First Publish Date: 04 February 2025

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