The Effect of Combined Training and Stevia Supplementation on Serum Asprosine Levels in Obese Patients with Type 2 Diabetes

Document Type : Original Article

Author

Assistant Professor of Exercise Physiology, Faculty of Humanities, Maragheh University, Maragheh, Iran.

Abstract

Aim: Inflammatory factors are known as an important mechanism in the occurrence of type 2 diabetes and metabolic diseases; while regular exercise has anti-inflammatory effects and suppresses low-grade systemic inflammation in type 2 diabetes. Therefore, the present study was conducted with the aim of investigating the effect of combined exercises with stevia supplementation on serum levels of asprosine, glucose and insulin resistance in obese women with type 2 diabetes.
Methods: 60 women with type 2 diabetes voluntarily participated in the study and were randomly divided into four groups. The subjects of the exercise group participated in selected sports exercises for 12 weeks and three sessions a week. One gram of stevia extract was taken daily, 15 minutes before the main meal. Fasting blood glucose, HbA1C, insulin resistance index and asprosin serum levels were measured.Results: The results of analysis of variance showed that there is a significant difference between the effects of different interventions in the serum levels of asprosine, blood glucose levels, HbA1C and insulin resistance. Combined exercises with stevia supplementation led to a decrease in the serum levels of asprosine in the exercise, supplement, exercise+supplement groups (p<0.001). But these changes were more significant in the exercise + supplement group.
Conclusion: It seems that both intervention methods of combined exercises and stevia supplementation are effective methods in controlling blood sugar and reducing inflammation, and the combination of these two methods is more effective in controlling glycaemia in patients with type 2 diabetes.

Keywords

Main Subjects

References

  1. Ghalavand A, Shakerian S, Zakerkish M, Shahbazian H, Monazam Nejad A. The effect of resistance training on anthropometric characteristics and lipid profile in men with type 2 diabetes referred to Golestan Hospital. Jundishapur Scientific Medical Journal. 2017;13(6):709-20.
  2. Pasdar Y, Moridi S, Najafi F, Niazi P, Heidary M. The effect of nutritional intervention and physical activities on weight reduction. Journal of Kermanshah University of Medical Sciences. 2012;15(6).
  3. Kratz M, Baars T, Guyenet S. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. European journal of nutrition. 2013;52(1):1-24.
  4. Strasser B. Physical activity in obesity and metabolic syndrome. Annals of the New York Academy of Sciences. 2013;1281(1):141-59.
  5. Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomedicine & Pharmacotherapy. 2021;137:111315.
  6. Ghalavand A, Mohammadpour M, Ghobadi MR, Motamedi P, Hovsepian A. Changes in the Serum Levels of Metabotropic Biomarkers (Asprosin and BDNF) in Adaptation to Aerobic Interval Training. Journal of Ilam University of Medical Sciences: Volume. 2023;31(2).
  7. Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, et al. Asprosin, a fasting-induced glucogenic protein hormone. Cell. 2016;165(3):566-79.
  8. Yuan M, Li W, Zhu Y, Yu B, Wu J. Asprosin: a novel player in metabolic diseases. Frontiers in endocrinology. 2020;11:512762.
  9. Zhang L, Chen C, Zhou N, Fu Y, Cheng X. Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride. Clinica chimica acta. 2019;489:183-8.
  10. Nieuwoudt S, Fealy CE, Foucher JA, Scelsi AR, Malin SK, Pagadala M, et al. Functional high-intensity training improves pancreatic β-cell function in adults with type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism. 2017;313(3):E314-E20.
  11. Hong T, Li J-Y, Wang Y-D, Qi X-Y, Liao Z-Z, Bhadel P, et al. High serum asprosin levels are associated with presence of metabolic syndrome. International journal of endocrinology. 2021;2021(1):6622129.
  12. Wang Y, Qu H, Xiong X, Qiu Y, Liao Y, Chen Y, et al. Plasma asprosin concentrations are increased in individuals with glucose dysregulation and correlated with insulin resistance and first‐phase insulin secretion. Mediators of inflammation. 2018;2018(1):9471583.
  13. Li X, Liao M, Shen R, Zhang L, Hu H, Wu J, et al. Plasma asprosin levels are associated with glucose metabolism, lipid, and sex hormone profiles in females with metabolic‐related diseases. Mediators of inflammation. 2018;2018(1):7375294.
  14. Wang M, Yin C, Wang L, Liu Y, Li H, Li M, et al. Serum asprosin concentrations are increased and associated with insulin resistance in children with obesity. Annals of nutrition and metabolism. 2020;75(4):205-12.
  15. Golpasasndi S, Abdollahpour S, Golpasandi H. High-intensity interval training combined with saffron supplementation modulates stress-inflammatory markers in obese women with type 2 diabetes. Research in Exercise Nutrition 2022;1(1):55-61.
  16. Hemmati Moghadam A, Rahmani Ghobadi M, SafiKhani H. The Effect of Six Weeks of High-Intensity CrossFit Training on Serum Asprosin, Body Fat Percentage and Insulin Resistance in Men with Type 2 Diabetes. Journal of Police Medicine. 2023;12(1):1-13.
  17. Zarei M, Nakhzari Khodakheyr J, Rashidlamir A, Montazeri A. The effect of combined resistance aerobic exercise training on concentrations of asprosin and complement C1q tumor necrosis factor-related protein-1 in men with type 2 diabetes. Sport Sciences for Health. 2021:1-9.
  18. Jeong I-Y, Lee H-J, Jin C-H, Park Y-D, Choi D-S, Kang M-A. Anti-inflammatory activity of Stevia rebaudiana in LPS-induced RAW 264.7 cells. Preventive Nutrition and Food Science. 2010;15(1):14-8.
  19. Akbari A, Tadibi V, Behpour N. The effect of stevia extract consumption and aerobic exercise on serum omentin-1 and lipid profile in STZ induced diabetic rats. Journal of sport biosciences. 2019;11(2):179-94.
  20. Chowdhury AI, Rahanur Alam M, Raihan MM, Rahman T, Islam S, Halima O. Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta‐analysis of preclinical studies. Food Science & Nutrition. 2022;10(9):2868-78.
  21. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes care. 2010;33(12):e147-e67.
  22. Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MAF, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia. Journal of Science and Medicine in Sport. 2012;15(1):25-31.
  23. Praet SF, van Loon LJ. Optimizing the therapeutic benefits of exercise in type 2 diabetes. Journal of applied physiology. 2007;103(4):1113-20.
  24. Sharifi E, Askari R, Haghighi AH. Comparision the effects of high and average intensity combined training on levels of serum heat shock proteins 70 and glycemic control in obese women with type 2 diabetes. Jundishapur Scientific Medical Journal. 2017;16(2):255-65.
  25. Baechle TR, Earle RW. Essentials of strength training and conditioning: Human kinetics; 2008.
  26. Yavari A, Najafipoor F, Aliasgarzadeh A, Niafar M, Mobasseri M. Effect of aerobic exercise, resistance training or combined training on glycaemic control and cardiovascular risk factors in patients with type 2 diabetes. Biology of Sport. 2012;29(2):135.
  27. Riyahi Malayeri S, Nafisi A, Behadari R. Effect of Stevia Consumption and Aerobic Exercise on Fat Profile and Insulin Resistance in Type 2 Diabetic men. medical journal of mashhad university of medical sciences. 2020;63(3):2380-90.
  28. Kajimura S. Advances in the understanding of adipose tissue biology. Nature reviews endocrinology. 2017;13(2):69-70.
  29. Li E, Shan H, Chen L, Long A, Zhang Y, Liu Y, et al. OLFR734 mediates glucose metabolism as a receptor of asprosin. Cell metabolism. 2019;30(2):319-28. e8.
  30. Gozel N, Kilinc F. Investigation of plasma asprosin and saliva levels in newly diagnosed type 2 diabetes mellitus patients treated with metformin. Endokrynologia Polska. 2021;72(1):37-43.
  31. Shabir K, Brown JE, Afzal I, Gharanei S, Weickert MO, Barber TM, et al. Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence. Cytokine & Growth Factor Reviews. 2021;60:120-32.
  32. Jung TW, Kim HC, Kim HU, Park T, Park J, Kim U, et al. Asprosin attenuates insulin signaling pathway through PKCδ‐activated ER stress and inflammation in skeletal muscle. Journal of cellular physiology. 2019;234(11):20888-99.
  33. Ko JR, Seo DY, Kim TN, Park SH, Kwak H-B, Ko KS, et al. Aerobic exercise training decreases hepatic asprosin in diabetic rats. Journal of clinical medicine. 2019;8(5):666.
  34. Calegari VC, Zoppi CC, Rezende LF, Silveira LR, Carneiro EM, Boschero AC. Endurance training activates AMP-activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets. Journal of Endocrinology. 2011;208(3):257.
  35. Nakhaei H, Mogharnasi M, Fanaei H. Effect of swimming training on levels of asprosin, lipid profile, glucose and insulin resistance in rats with metabolic syndrome. Obesity medicine. 2019;15:100111.
  36. Ceylan Hİ, Saygın Ö. An investigation of the relationship between new fasting hormone asprosin, obesity and acute–chronic exercise: current systematic review. Archives of Physiology and Biochemistry. 2021;127(4):373-84.
  37. Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute anaerobic exercise affects the secretion of asprosin, irisin, and other cytokines–a comparison between sexes. Frontiers in physiology. 2018;9:423615.
  38. Akbarzadeh S, Eskandari F, Tangestani H, Bagherinejad ST, Bargahi A, Bazzi P, et al. The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats. Journal of dietary supplements. 2015;12(1):11-22.
  39. Assaei R, Mokarram P, Dastghaib S, Darbandi S, Darbandi M, Zal F, et al. Hypoglycemic effect of aquatic extract of Stevia in pancreas of diabetic rats: PPARγ-dependent regulation or antioxidant potential. Avicenna journal of medical biotechnology. 2016;8(2):65.
  40. Komissarenko N, Derkach A, Kovalev I, Bublik N, Chermeneva G, Komov A, et al. Diterpenoid glycosides and phenylpropanoids of Stevia rebaudiana Bertoni (Asteraceae) leaves. 1994.
  41. Chen T-H, Chen S-C, Chan P, Chu Y-L, Yang H-Y, Cheng J-T. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta medica. 2005;71(02):108-13.
  42.  
Research in Exercise Nutrition
Volume 2, Issue 4 - Serial Number 4
February 2024
Pages 100-81

Files

History

  • Receive Date: 08 October 2024
  • Revise Date: 20 November 2024
  • Accept Date: 03 December 2024
  • First Publish Date: 03 December 2024

Share

How to cite

Statistics