The effect of 6 weeks of endurance training with berberine supplementation on the lipid profile of obese rats

Document Type : Original Article

Authors

1 Department of Physical Education and Sport Sciences, Islamic Azad University, Yazd Branch, Yazd, Iran.

2 Department of Physical Education and Sport Sciences, Islamic Azad University, Kerman Branch, Kerman, Iran.

Abstract

Aims: The purpose of this research is The effect of a course of endurance training with berberine supplementation on the lipid profile of obese rats.

Methods: Number of 40 fat 6-month-old rats with an average weight of 320-380 gr were randomly divided into 4 groups of 10 (control, endurance exercise, berberine supplement and exercise-berberine). The exercise-supplement and endurance exercise groups trained 5 times a week for 6 weeks. The supplement and exercise-supplement groups were also given 5 servings of berberine supplement per kilogram of body weight 5 times a week. It was gavage. 24 hours after the last training session, the subjects were fasted, anesthetized, and blood was drawn from the rats. method was used. Analysis and analysis of data was done using spss software version 26 and at the level of significance (P≥0.05).

Results: The results of the research showed that a course of endurance training and berberine supplementation had a significant effect on all lipid profiles of obese rats. It didn't happen.

Conclusion: According to the results of the present study, it seems that the simultaneous use of endurance training and berberine supplement can be considered as a solution to improve lipid profile indicators in obese people.


Keywords

Main Subjects

References

  1.  Ahmadi M, Abbassi Daloii A, Behbudi L. Comparison between the effects of eight weeks of aerobic and resistance training on paraoxonase-1, arylesterase activity and lipid profile in obese girls. Scientific Journal of Kurdistan University of Medical Sciences. 2016;21(4):83-93.
  2. Khalafi M, Sakhaei MH, Kazeminasab F, Rosenkranz SK, Symonds ME. Exercise training, dietary intervention, or combined interventions and their effects on lipid profiles in adults with overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Nutrition, Metabolism and Cardiovascular Diseases. 2023;33(9):1662-83.
  3. Sadeghi F, Miri N, Barikani A, Hossein Rashidi B, Ghasemi Nejad A, Hojaji E, et al. Comparison of Food intake, physical activity and weight in infertile and healthy women aged 25-40 years. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2015;18(173):32-40.
  4. Shepherd SO, Wilson OJ, Taylor AS, Thøgersen-Ntoumani C, Adlan AM, Wagenmakers AJ, et al. Low-volume high-intensity interval training in a gym setting improves cardio-metabolic and psychological health. PloS one. 2015;10(9):e0139056.
  5. Balaguera-Cortes L, Wallman KE, Fairchild TJ, Guelfi KJ. Energy intake and appetite-related hormones following acute aerobic and resistance exercise. Applied Physiology, Nutrition, and Metabolism. 2011;36(6):958-66.
  6. Okdan B, Nalcakan GR, Onur E, Oran A, Nalcakan M. Effect of folk dance training on blood oxidative stress level, lipids, and lipoproteins. Polish Journal of Sport and Tourism. 2016;23(3):133-9.
  7. Fakhri F, Fakhri S, Shakeryan S, Alizadeh A. The Effect of short–term nanocurcumin supplementation on the anthropometric indices, lipid Profile and C-Reactive protein of overweight girls. Complementary Medicine Journal. 2020;10(1):94-105.
  8. Ghadimi M, Elmieh A, Nia FR, Zidashti ZH, Azarbayjani MA. Comparison of effects of endurance training and consumption of berberine chloride hydrate on the liver enzymes and serum blood glucose in Wistar rats with type 2 diabetes: an experimental study. 2019.
  9. Cao C, Su M. Effects of berberine on glucose-lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndrome. Experimental and therapeutic medicine. 2019;17(4):3009-14.
  10. Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta medica. 2013;79(06):437-46.
  11. Kavyani Z, Moridpour AH, Falahatzadeh M, Vajdi M, Musazadeh V, Askari G. The effect of berberine supplementation on lipid profile and obesity indices: an umbrella review of meta-analysis. PharmaNutrition. 2023:100364.
  12. Derosa G, D'Angelo A, Bonaventura A, Bianchi L, Romano D, Maffioli P. Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert opinion on biological therapy. 2013;13(4):475-82.
  13. Zarei A, Taheri S, Changizi Ashtiyani S, Rezaei A. The study of the effect of the extract Berberis Vulgaris root on serum levels of thyroid hormones in hypercholesterolemia rats. Iranian South Medical Journal. 2015;18(2).
  14. Nejati L, Movahedi A, Salari G, Moeineddin R, Nejati P. The effect of berberine on lipid profile, liver enzymes, and fasting blood glucose in patients with non-alcoholic fatty liver disease (NAFLD): a randomized controlled trial. Medical Journal of the Islamic Republic of Iran. 2022;36.
  15. Salehi A, Abbaszadeh H, Farzanegi P. The Effect of Periodic Exercise and Resveratrol Supplementation on the Expression of Pparg Coactivator-1 Alpha and Pyruvate Dehydrogenase Kinase Genes in Gastrocnemius Muscle of Old Rats With Type 2 Diabetes. Internal Medicine Today. 2019;26(1):68-81.
  16. Fattahi Bafghi A, Homaee HM, Azarbayjani MA. Effects of high intensity interval training and curcumin supplement on antioxidant enzyme in heart tissue of diabetic rats. Iranian Journal of Diabetes and Obesity. 2016;8(3):135-41.
  17. León-Martínez JM, Martínez-Abundis E, González-Ortiz M, Pérez-Rubio KG. Effect of berberine plus bezafibrate administration on the lipid profile of patients with mixed dyslipidemia: a pilot clinical trial. Journal of medicinal food. 2021;24(2):111-5.
  18. Naghizadeh H, Heydari F. The effect of 12 weeks of high-intensity interval training and curcumin consumption on plasma levels of IL-6, TNF-alpha and CRP in men with type II diabetes along with hyperlipidemia. Journal of Practical Studies of Biosciences in Sport. 2023;11(25):22-36.
  19. Kadkhoda Z, Khajeie R, Barjaste Yazdi A, Safipor Afshar A, Zarei M. Effect of Eight Weeks of High-Intensity Interval Training Along With Purslane Consumption on Lipid Profile of Rats with Non-alcoholic Fatty Liver Disease. Complementary Medicine Journal. 2022;12(3):270-83.
  20. Cai Y, Yang Q, Yu Y, Yang F, Bai R, Fan X. Efficacy and underlying mechanisms of berberine against lipid metabolic diseases: a review. Frontiers in pharmacology. 2023;14:1283784.

 

Research in Exercise Nutrition
Volume 2, Issue 3
October 2024
Pages 120-101

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