Effect of aerobic exercise on fetoin A: elucidating the relationship between obesity and related metabolic problems

Document Type : Review Articles

Author

Department of Physical Education and Sports Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.

Abstract

Fetuin-A is a glycoprotein that is mainly secreted by the liver and adipose tissue, and its role in the promotion of adipose tissue inflammation has been shown. Epidemiological studies have shown a significant increase in circulating Fetuin-A in obesity and its related complications such as type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD); and it has been proven that the reduction of Fetuin-A reduces the occurrence of obesity-related disorders. On the other hand, exercise activity and lifestyle modification is one of the effective strategies for obesity prevention and treatment, and several studies have reported the reduction of obesity-related complications following exercise activity. However, there are conflicting results regarding the effect of aerobic exercise on Fetuin-A. In this review, the current knowledge about the origin and physiology of Fetuin-A is presented, the effect of aerobic exercise on the regulation of Fetuin-A in obesity is summarized, and the mechanism of the effect of aerobic exercise on Fetuin-A is discussed. Overall, aerobic exercise can be one of the effective strategies for controlling and treating obesity and related disorders through different mechanisms that ultimately leads to the reduction of Fetuin-A.

Keywords

Main Subjects

References

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Research in Exercise Nutrition
Volume 2, Issue 2
March 2024
Pages 60-47

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History

  • Receive Date: 15 December 2023
  • Revise Date: 10 March 2024
  • Accept Date: 10 March 2024
  • First Publish Date: 10 March 2024

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