Effects of aerobic training and Fed with High Fat Diet on Kiss1 , Kisspeptin receptor mRNA expression of Testis, LH and FSH in Adolescent male rats

Document Type : Original Article

Authors

1 Department of Physical Education, Tabriz branch, Islamic Azad University, Tabriz, Iran .

2 Department of Physical Education, Tabriz branch, Islamic Azad University, Tabriz, Iran.

3 Department of Veterinary, Tabriz branch, Islamic Azad University, Tabriz, Iran.

Abstract

Aims: This study aimed to investigate the effects of aerobic training and a high-fat diet on the expression of Kiss1 and Kisspeptin receptor mRNA in the testes, and levels of LH and FSH in adolescent male rats.
Methods: Forty young male rats (30 days old) were randomly assigned to one of four groups: normal diet control (NDC), normal diet training (NDT), high fat diet control (HFDC), and high fat diet training (HFDT). The rats in the HFD groups were fed a high-fat diet (5.817 kcal/g) for 30 days, while the normal diet (3.801 kcal/g) was continued until the 60th day of their life. Aerobic training was carried out for four weeks and involved three training sessions from the 70th to 98th days of their life.
Results: The results showed that high-fat diet caused a significant decrease in kisspeptin and gonadal kisspeptin receptor content of male rats, and exercise also increased them. Also, the high-fat diet caused a significant decrease in the amount of LH hormone in the blood of male rats, and exercise also increased it. Exercise training increased circulating FSH and high-fat diet decreased FSH in male rats.
Conclusion: Overall, the results showed that a high-fat diet decreases the amount of kisspeptin and its receptor in the testicles of rats along with a decrease in circulating FSH and LH hormones. On the other hand, aerobic exercise has completely opposite effects to a high-fat diet; However, it is only partially able to compensate for this negative effect caused by a high-fat diet, and in any case, it is not able to eliminate all its bad effects.

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Research in Exercise Nutrition
Volume 1, Issue 3
November 2022
Pages 11-22

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History

  • Receive Date: 21 November 2023
  • Revise Date: 03 December 2023
  • Accept Date: 10 December 2023
  • First Publish Date: 10 December 2023

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