High-intensity interval training combined with saffron supplementation modulates stress-inflammatory markers in obese women with type 2 diabetes

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 PhD student of medical physiology, Department of Medical Physiology, Faculty of Medicine, Kankuk University, Seoul, South Korea.

2 Master of exercise physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Guilan, Iran.

3 Ph.D of exercise physiology, Department of Exercise physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.

10.34785/J019.2022.002

Abstract

Introduction: The aim of this study was to investigate the interactive effects of saffron extract supplementation with high-intensity interval training (HIIT) on serum levels of stress-inflammatory markers in obese women with type 2 diabetes.

Method: Thirty-two obese women with type 2 diabetes were randomly divided into 4 intervention groups: supplement, HIIT +Supplement, placebo and placebo+ HIIT. The anthropometric and blood characteristics of subjects were evaluated in pre-test and post-test. The method of supplementation was that the supplement group received 100 mg of saffron extract daily. The subjects in the training group also did running on the treadmill in 4 bouts with intensity of 85 to 95% of the maximum heart rate along with 4 periods of active rest at the intensity of 50 to 60% of the maximum heart rate.

Results: Data analysis showed that the effect of time was a significant decrease in serum levels of IL-6, NT-proBNP, and GDF-15 in the supplement, supplement+ HIIT and placebo+ HIIT groups (P≤0.05). The results of time × group interaction also showed a significant difference between the groups (P≤0.05). So that the decrease in the levels of stress-inflammatory markers in the supplement+ HIIT group had a greater decrease.

Conclusion: According to the results, it can be reported that HIIT and saffron supplementation (combination of both) probably reduces the levels of stress-inflammatory markers such as GDF-15, NT-proBNP, and IL-6 by reducing fat mass, as well as also improve glucose metabolism and insulin resistance in obese women with diabetes.

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History

  • Receive Date: 03 January 2022
  • Revise Date: 10 February 2022
  • Accept Date: 25 February 2022
  • First Publish Date: 22 May 2022

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