The Effect of Salvia Officinalis Extract on P53 and Creatine Kinase Levels in Downhill Running: A Crossover Randomized, Double-Blind, and Placebo-Controlled Study

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Assistant Professor of exercise physiology, Department of Physical Education, Faculty of Humanities, Marivan Azad University, Marivan, Kurdistan, Iran.

2 Associate Professor of exercise physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran.

3 Master of exercise physiology, Department of exercise physiology،, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Kurdistan, Iran

10.34785/J019.2022.392

Abstract

The effect of salvia officinalis (Sage) extract on levels of p53 and creatine kinase (CK) after eccentric exercise is unclear.
Objective: In the present study, the effect of salvia officinalis extract on serum levels of p53 and CK after a downhill running was investigated
Methods: 14 healthy men (age, 24.4±3.5 yr; body mass index, 22.46±1.5 kg/m2) were randomly placed in two conditions of sage and placebo. Subjects took 500 mg capsules of sage extract (two daily) or placebo for two weeks. After 14 days, subjects performed downhill running at 12% downhill grade at about 70% of the maximum heart rate until volitional exhaustion (30 minutes). Blood sampling was performed before and immediately after the running workout for the measurement of the serum p53 and CK concentrations.
Results: The results showed that in the sage condition, the changes in p53 levels in the before exercise compared to the after running were not statistically significant (p = 0.14). In the placebo condition, p53 levels in the post- running increased significantly compared to the pre- running (p = 0.001). Also, CK levels in the post-running only in the placebo condition increased significantly compared to the pre- running (p = 0.007).
Conclusion: The findings of the present study showed that downhill running as eccentric contraction may lead to cell apoptosis and muscle damage by increasing p53 and CK levels, but short-term sage supplementation is likely inhibits increased apoptosis and muscle damage marker in serum induced by acute exercise.

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History

  • Receive Date: 03 December 2021
  • Revise Date: 05 January 2022
  • Accept Date: 14 February 2022
  • First Publish Date: 14 February 2022

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