اثر مکمل دهی ال- آرژنین بر پاسخ VEGF و اندوستاتین طی فعالیت هوازی وامانده ساز در کشتی‌گیران

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران.

2 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران.

3 گروه علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران.

چکیده

هدف: در این مطالعه اثر یک دوره مصرف مکمل ال-آرژنین بر پاسخ‌های VEGF و اندوستاتین طی یک جلسه فعالیت مقاومتی وامانده‌ساز در کشتی‌گیران بررسی گردید.

روش شناسی: 15 کشتی‌گیر با میانگین سنی 21.13±2.47 سال و نمایه‌ی توده بدنی 24.1±2.3کیلوگرم بر متر مربع به روش نمونه‌گیری داوطلبانه و هدفدار انتخاب و به صورت تصادفی در دو گروه مکمل (8 نفر) و دارونما (7 نفر) قرار گرفتند. در پیش‌آزمون و پس‌آزمون، آزمودنی‌ها پروتکل وامانده‌ساز بروس را تا رسیدن به واماندگی انجام دادند و نمونه‌گیری خون قبل و بلافاصله بعد از پروتکل بروس گرفته شد. افراد در گروه مکمل به مدت 45 روز مکمل آرژنین ( 0.1 گرم به ازای هر کیلوگرم وزن بدن) دریافت کردند و گروه دارونما (مالتودکسترین) دریافت کردند. هر دو گروه مطابق با هفته‌های گذشته تمرینات تخصصی خود را در دوره مکمل انجام دادند. سطح فاکتور رشد اندوتلیال عروقی (VEGF) و اندوستاتین سرم با الایزا اندازه‌گیری گردید. تجزیه و تحلیل آماری داده‌ها با استفاده از آزمون t همبسته و مستقل انجام شد.

یافته‌ها: تغییرات VEGF، اندوستاتینو همچنین نسبت VEGF به اندوستاتین در کشتی‌گیرانی پس از یک دوره مکمل دهی آرژنین و متعاقب یک جلسه آزمون بروس وامانده‌ساز از نظر آماری معنی‌دار نبودند (05/0P˃).

نتیجه گیری: اگرچه یافته‌‌های تحقیق حاضر از نظر آماری معنی‌دار نبودند، اما به نظر می‌رسد که استفاده از مکمل آرژنین با افزایش نسبی VEGF و نسبت VEGF به اندوستاتین و همچنین کاهش اندوستاتین در گروه مکمل، منجر به توسعه نسبی فرآیند رگ‌زایی شود.

تازه های تحقیق

 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of L-arginine supplementation on VEGF and endostatin responses during exhaustive aerobic exercise in wrestlers

نویسندگان [English]

  • Mohammad Rahman Rahimi 1
  • Seyed Hossein Hosseinimehr 2
  • Sirwan Khaledi 3
1 Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
2 Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
3 Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
چکیده [English]

Aim: This study investigates the effect of L-arginine supplementation on VEGF and endostatin responses during a session of Bruce exhaustive protocol in wrestlers.

Method: Fifteen wrestlers, with a mean age of 21.13±2.47 years and a body mass index of 24.1±2.3 kg/m², were selected through voluntary and purposive sampling and randomly assigned to two groups: supplement (n=8) and placebo (n=7). In both the pre-test and post-test, subjects performed the Bruce exhaustive protocol until exhaustion, and blood samples were taken before and immediately after the protocol. Subjects in the supplement group received L-arginine supplementation (0.1 g/kg body weight) for 45 days, while the placebo group received maltodextrin. Both groups continued their specialized training during the supplementation period as in previous weeks. Serum VEGF and endostatin levels were measured using ELISA. Statistical analysis of the data was performed using paired and independent t-tests.

Results: Changes in VEGF, endostatin, and the VEGF to endostatin ratio in wrestlers after a period of arginine supplementation and following a session of the Bruce exhaustion test were not statistically significant (P > 0.05).

Conclusion: Although the findings of this study were not statistically significant, it appears that L-arginine supplementation, with a relative increase in VEGF and the VEGF to endostatin ratio, and a decrease in endostatin in the supplementation group, may contribute to the development of the angiogenesis process.

کلیدواژه‌ها [English]

  • Wrestlers
  • L-arginine
  • VEGF VEGF
  • endostatin
  • angiogenesis

اصل مقاله

 

Publisher: University of Kurdistan         Copyright © The Authors

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

 

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پژوهش در تغذیه ورزشی
دوره 3، شماره 1
فروردین 1403
صفحه 81-73

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سابقه مقاله

  • تاریخ دریافت: 21 بهمن 1403
  • تاریخ بازنگری: 01 اسفند 1403
  • تاریخ پذیرش: 01 اسفند 1403
  • تاریخ اولین انتشار: 01 اسفند 1403

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