بررسی اثر تعاملی هشت هفته تمرین استقامتی- مقاومتی و مصرف مکمل تورین بر آلدسترون، رنین- آنژیوتانسین در موش نر ویستار دیابتی شده با استروپتوزوسین

نوع مقاله : مقاله اصیل

نویسندگان

1 گروه فیزیولوژی ورزشی،دانشکده علوم تربیتی و روانشناسی،دانشگاه محقق اردبیلی، اردبیل، ایران.

2 گروه فیزیولوژی ورزشی، دانشکده علوم تربیتی و روانشناسی ، دانشگاه محقق اردبیلی، اردبیل، ایران.

3 گروه فیزیولوژی ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.

چکیده

هدف: هدف از تحقیق حاضر بررسی اثر تعاملی هشـت هفتـه تمـرین استقامتی- مقـاومتی و مصرف مکمل تورین بر سطح آلدوسترون، رنین و آنژیوتانسین در موش های نر ویستار دیابتی شده بود.

روش شناسی: در این مطالعه تجربی از تعداد 50 رت نر ویستار، 40 رت نر ویستار بعد از القای دیابت بـا تزریـق داخل ٥٥ میلیگرم بر کیلوگرم استروپتوزوسین حل شده در بـافر سـیترات (٠٥/٠ مولار با ٥/٤ =pH ) در 5 گروه تمرین دیابتی (10=n)، مکمل دیابتی (10=n)،گروه تمرین- مکمل (10=n)، کنترل دیابتی (10=n) و گروه کنترل سالم (10=n) رت قرار گرفتند.. بعد از بیهوشی و گرفتن نمونه‌های خونی متغیرهای رنین، آلدسترون و آنژیوتانسین اندازه‌گیری شد. برای مقایسه میانگین متغیرها در گروه‌های مختلف، ANOVA یک طرفه و برای تعیین تفاوت بین گروه‌ها از آزمون تعقیبی بونفرنی استفاده شد. سطح معنی‌داری آزمون‌ها 05/0 > P در نظر گرفته شد.

یافته ها:. نتایج یافته‌های آزمون نشان داد در پایان هشت هفته، بین سطح سرمی آلدسترون گروه‌های تمرین-دیابتی، مکمل دیابتی، تمرین-مکمل دیابتی، کنترل دیابتی و کنترل سالم و رنین و آنژیوتانسین گروه‌های تمرین دیابتی، مکمل دیابتی، تمرین-مکمل دیابتی، کنترل دیابتی و کنترل سالم تفاوت معنی‌داری وجود دارد( 0001/0=P).

نتیجه گیری: هشت هفته تمرین استقامتی- مقاومتی و مصرف مکمل تورین باعث کاهش معنی-دار آلدوسترون رنین و کاهش آنژیوتانسین و در موش‌های نر ویستار دیابتی شده با استروپتوزوسین شد. لذا، احتمالاً ترکیب تمرین استقامتی- مقاومتی به همراه مصرف مکمل تورین می‎تواند برای کنترل فشارخون بالا که از عوارض بیماری دیابت بر هورمونهای کلیوی هست ،مناسب باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Interactive effect of an eight-week period of endurance-resistance training and taurine supplementation on aldosterone, renin-angiotensin in in streptozotocin-induced diabetic male Wistar rats

نویسندگان [English]

  • Niloofar Rajaei ghasem gheshlaghi 1
  • Ameneh Pourrahim 2
  • Aidin Valizadeh 3
1 Department of Sport Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
2 Department of Sports Physiology, Faculty of Educational Sciences and Psychology, Mohaghegh Ardebili University, Ardebil, Iran.
3 Department of Physiological Sciences, Mohaghegh Ardabili University, Ardabil, Iran
چکیده [English]

Aim: The purpose of this research was to investigate the interactive effect of eight weeks of endurance-resistance training and taurine supplementation on the levels of aldosterone, renin and angiotensin in diabetic male Wistar rats.

Methods: In this experimental study, out of 50 male Wistar rats, 40 male Wistar rats after induction of diabetes by injecting 55 mg/kg of streptozocin dissolved in citrate buffer (0.05 M with pH = 4.5) were divided into 5 groups. Diabetic exercise (n=10), diabetic supplement (n=10), exercise-supplement group (n=10), diabetic control (n=10) and healthy control group (n=10) were included. One-way ANOVA was used to compare the average of variables in different groups, and Bonferroni's post hoc test was used to determine the difference between groups. The significance level of the tests was considered P>0.05.

Results: The results of the test showed that at the end of eight weeks, there was a difference between the serum levels of aldosterone in the groups of exercise-diabetic, diabetic supplement, exercise-diabetic supplement, diabetic control and healthy control, and renin and angiotensin in the groups of diabetic exercise, diabetic supplement, exercise-diabetic supplement, and diabetic control. and healthy control there is a significant difference (P=0.0001).

Conclusion: Eight weeks of endurance-resistance training and taurine supplementation caused a significant decrease in aldosterone, renin, and angiotensin in male Wistar rats treated with streptozocin. Therefore, probably, the combination of endurance-resistance training with taurine supplementation can be suitable for controlling high blood pressure, which is one of the complications of diabetes on renal hormones.

کلیدواژه‌ها [English]

  • renin
  • angiotensin
  • aldosterone
  • taurine
  • endurance-resistance training

مراجع

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  • تاریخ دریافت: 27 خرداد 1403
  • تاریخ بازنگری: 14 مرداد 1403
  • تاریخ پذیرش: 13 شهریور 1403
  • تاریخ اولین انتشار: 13 شهریور 1403

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