تاثیر 8 هفته تمرینات HICT همراه با مصرف عصاره برگ زیتون بر سطوح سرمی لپتین و آدیپونکتین در زنان سالمند چاق

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم‌ ورزشی، دانشکده علوم اجتماعی، دانشگاه رجا ، قزوین، ایران

2 دکتری فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه محقّق اردبیلی، اردبیل، ایران.

3 کارشناس تربیت بدنی و علوم ورزشی، گروه تربیت‌بدنی و علوم‌ ورزشی، دانشکده علوم اجتماعی، دانشگاه بین المللی امام خمینی ، قزوین، ایران

چکیده

هدف: آدیپونکتین و لپتین دو هورمون پپتیدی تنظیم کننده تعادل انرژی هستند. هدف از این مطالعه، تاثیر 8 هفته تمرینات HICT همراه با مصرف عصاره برگ زیتون بر سطوح سرمی لپتین و آدیپونکتین در زنان سالمند چاق بود.

روش‌شناسی: در این مطالعه نیمه تجربی بالینی 40 زن سالمند چاق به طور تصادفی درچهار گروه گروه دارونما، گروه عصاره،گروه تمرین و گروه عصاره + تمرین به طور مساوی قرار گرفتند. تمرینات به مدت هشت هفته و سه جلسه در هفته به مدت 45 تا 60 دقیقه انجام شد. آزمودنی ها به مدت هشت هفته، روزی یک عدد کپسول 125 میلی‌گرمی عصاره برگ زیتون را بعد از ناهار مصرف کردند. متغیر خونی لپتین و آدیپونکتین 48 ساعت قبل و بعد از آزمون، اندازه‌گیری شدند. 

یافته ها: در طول آزمون تی زوجی در گروه‌های تمرین و تمرین+ عصاره کاهش معنادار (1)لپتین و افزایش معنادار سطح آدیپونکتین مشاهده شد. (05/0P<). از نظر درصد تغییر، گروه عصاره + تمرین کاهش بیشتری در مقادیر لپتین(23.43 درصد ) و افزایش بیشتری در مقدار آدیپونکتین (23.22 درصد) نسبت به پیش‌آزمون نشان می‌دهد. استفاده از آزمون تحلیل کوواریانس جهت مقایسه نتایج بین گروهی اختلاف معناداری را در شاخص لپتین (01/0= P، 10/17=F) و آدیپونکتین (001/0= P، 38/12=F) نشان داد.

نتیجه گیری: با توجه به نتایج ، تجویز یک برنامه ترکیبی در کنار مصرف عصاره برگ زیتون، در سالمندان مبتلا به دیابت نوع 2 می‌تواند بیشترین تأثیر را در بهبود مقادیر لپتین و آدیپونکتین در زنان سالمند چاق دیابتی داشته باشد.

تازه های تحقیق

 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of 8 weeks of HICT training combined with olive leaf extract consumption on serum leptin and adiponectin levels in obese elderly women.

نویسندگان [English]

  • Ali Akbari 1
  • Seyed hamed Ghiyami 2
  • Samira Ghasabi 3
  • Roya Mahmoodi 1
1 Master of Sports Physiology, Department of Physical Education and Sport Sciences, Faculty of Social Sciences, Raja University, Qazvin, Iran
2 PhD Student in Sports Physiology, Department of Physical Education and Sports Sciences, Faculty of Educational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil, Iran.
3 - Physical Education and Sports Science Expert, Department of Physical Education and Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
چکیده [English]

Aims: Adiponectin and leptin are two peptide hormones that regulate energy balance. The aim of this study was the effect of 8 weeks of HICT exercises with olive leaf extract on serum levels of leptin and adiponectin in obese elderly women.

Method: In this semi-experimental clinical study, 40 obese elderly women with type 2 diabetes were randomly divided into four groups: placebo group, extract group, exercise group, and extract + exercise group. The exercises were performed for eight weeks and three sessions per week for 45 to 60 minutes. Subjects took one 125 mg capsule of olive leaf extract after lunch for eight weeks. Leptin and adiponectin blood variables were measured 48 hours before and after the test.

Results: During the paired t-test, a significant decrease (1) in leptin and a significant increase in adiponectin levels were observed in the exercise and exercise + extract groups. (P<0.05). In terms of percentage change, the extract + exercise group showed a greater decrease in leptin levels (23.43%) and a greater increase in adiponectin levels (23.22%) compared to the pre-test. Using the analysis of covariance test to compare the results between groups, a significant difference was found in the leptin index (P=0.01, F=17.10) and adiponectin (P=0.001, F=12.38).

Conclusion: According to the results, prescribing a combined program along with the consumption of olive leaf extract in the elderly with type 2 diabetes can have the greatest effect in improving leptin and adiponectin levels in obese diabetic elderly women.

کلیدواژه‌ها [English]

  • high-intensity circuit training
  • leptin
  • adiponectin
  • olive leaf

اصل مقاله

 

Publisher: University of Kurdistan         Copyright © The Authors

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

 

مراجع

  • [1] Esmaieli M, Abedi B, Fathollahi Shoorabeh F. Effect of aerobic training with Chlorella supplement on insulin resistance and serum ghrelin levels in obese women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018;21(10):48-56, Doi: https://doi.org/10.22038/ijogi.2018.12245 .
  • [2] Castaner O, Goday A, Park Y-M, Lee S-H, Magkos F, Shiow S-ATE, et al. The gut microbiome profile in obesity: a systematic review. International journal of endocrinology. 2018;2018, Doi: https://doi.org/10.1155/2018/4095789 .
  • [3] Atawia RT, Bunch KL, Toque HA, Caldwell RB, Caldwell RW. Mechanisms of obesity-induced metabolic and vascular dysfunctions. Frontiers in bioscience (Landmark edition). 2019;24:890, Doi: https://doi.org/10.2741/4758 .
  • [4] Abarca-Gómez L, Abdeen ZA, Hamid ZA, Abu-Rmeileh NM, Acosta-Cazares B, Acuin C, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128· 9 million children, adolescents, and adults. The lancet. 2017;390(10113):2627-42, Doi: https://doi.org/10.1016/S0140-6736(17)32129-3 .
  • [5] Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. Journal of Biological chemistry. 1995;270(45):26746-9, Doi: https://doi.org/10.1074/jbc.270.45.26746 .
  • [6] Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of clinical investigation. 2006;116(7):1784-92, Doi: https://doi.org/10.1172/JCI29126 .
  • [7] Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. The Journal of Clinical Endocrinology & Metabolism. 2001;86(5):1930-5, Doi: https://doi.org/10.1210/jcem.86.5.7463 .
  • [8] Friedman J. Leptin at 20: an overview. J Endocrinol. 2014;223(1):T1-8, Doi: http://dx.doi.org/10.1530/JOE-14-0405.
  • [9] Paz-Filho G, Mastronardi C, Franco CB, Wang KB, Wong M-L, Licinio J. Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications. Arquivos Brasileiros de Endocrinologia & Metabologia. 2012;56:597-607, Doi: https://doi.org/10.1590/S0004-27302012000900001 .
  • [10] Ghadge AA, Khaire AA. Leptin as a predictive marker for metabolic syndrome. Cytokine. 2019;121:154735, Doi: https://doi.org/10.1016/j.cyto.2019.154735 .
  • [11] Thompson WG, Cook DA, Clark MM, Bardia A, Levine JA, editors. Treatment of obesity. Mayo Clinic proceedings; 2007: Elsevier, Doi: https://doi.org/10.4065/82.1.93 .
  • [12] Alamout MM, Rahmanian M, Aghamohammadi V, Mohammadi E, Nasiri K. Effectiveness of mindfulness based cognitive therapy on weight loss, improvement of hypertension and attentional bias to eating cues in overweight people. International journal of nursing sciences. 2020;7(1):35-40, Doi: https://doi.org/10.1016/j.ijnss.2019.12.010.
  • [13] Bray GA, Tartaglia LA. Medicinal strategies in the treatment of obesity. Nature. 2000;404(6778):672-7, Doi: https://doi.org/10.1038/35007544 .
  • [14] Fki I, Sayadi S, Mahmoudi A, Daoued I, Marrekchi R, Ghorbel H. Comparative study on beneficial effects of hydroxytyrosol-and oleuropein-rich olive leaf extracts on high-fat diet-induced lipid metabolism disturbance and liver injury in rats. BioMed Research International. 2020;2020, Doi: https://doi.org/10.1155/2020/1315202 .
  • [15] Haidari F, Shayesteh F, Mohammad-Shahi M, Jalali MT, Ahmadi-Angali K. Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial. Clin Nutr Res. 2021;10(4):314-29, Doi: https://doi.org/10.7762/cnr.2021.10.4.314.
  • [16] Salah MB, Abdelmelek H, Abderraba M. Study of phenolic composition and biological activities assessment of olive leaves from different varieties grown in Tunisia. Med chem. 2012;2(5):107-1, Doi: 4172/2161-0444.1000124 .
  • [17] Tabera J, Guinda Á, Ruiz-Rodríguez A, Señoráns FJ, Ibáñez E, Albi T, et al. Countercurrent supercritical fluid extraction and fractionation of high-added-value compounds from a hexane extract of olive leaves. Journal of Agricultural and Food Chemistry. 2004;52(15):4774-9, Doi: https://doi.org/10.1021/jf049881.
  • [18] Shen Y, Song SJ, Keum N, Park T. Olive leaf extract attenuates obesity in high-fat diet-fed mice by modulating the expression of molecules involved in adipogenesis and thermogenesis. Evidence-Based Complementary and Alternative Medicine. 2014;2014, Doi: https://doi.org/10.1155/2014/971890 .
  • [19] Kim Y, Choi Y, Park T. Hepatoprotective effect of oleuropein in mice: mechanisms uncovered by gene expression profiling. Biotechnology journal. 2010;5(9):950-60, Doi: https://doi.org/10.1002/biot.201000068 .
  • [20] Hsu C-L, Wu C-H, Huang S-L, Yen G-C. Phenolic compounds rutin and o-coumaric acid ameliorate obesity induced by high-fat diet in rats. Journal of agricultural and food chemistry. 2009;57(2):425-31, Doi: https://doi.org/10.1021/jf802715t.
  • [21] Roriz AKC, Passos LCS, de Oliveira CC, Eickemberg M, Moreira PdA, Sampaio LR. Evaluation of the accuracy of anthropometric clinical indicators of visceral fat in adults and elderly. PloS one. 2014;9(7):e103499, Doi: https://doi.org/10.1371/journal.pone.0103499.
  • [22] Lean ME. Management of obesity and overweight. Medicine. 2019;47(3):175-83, Doi: https://doi.org/10.1136/bmj.325.7367.757 .
  • [23] Ouerghi N, Fradj MK, Duclos M, Bouassida A, Feki M, Weiss K, Knechtle B. Effects of high-intensity interval training on selected adipokines and cardiometabolic risk markers in normal-weight and overweight/obese young males—A pre-post test trial. Biology. 2022 Jun 2;11(6):853, Doi: https://doi.org/10.3390/biology11060853.
  • [24] Fealy CE, Nieuwoudt S, Foucher JA, Scelsi AR, Malin SK, Pagadala M, et al. Functional high‐intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes. Experimental physiology. 2018;103(7):985-94, Doi: https://doi.org/10.1113/EP086844 .
  • [25] Saghebjoo M, Farrokhi-Fard M, Hedayati M, Sadeghi-Tabas S. The effect of high-intensity interval training and L-arginine supplementation on the serum levels of adiponectin and lipid profile in overweight and obese young men. Obesity Medicine. 2019;16:100139, Doi: https://doi.org/10.1016/j.obmed.2019.100139 .
  • [26] TaheriChadorneshin H, Cheragh-Birjandi S, Goodarzy S, Ahmadabadi F. The impact of high intensity interval training on serum chemerin, tumor necrosis factor-alpha and insulin resistance in overweight women. Obesity medicine. 2019;14:100101, Doi: https://doi.org/10.1016/j.obmed.2019.100101.
  • [27] Aktaş H, Uzun Y, Kutlu O, Pençe H, Özçelik F, Çil E, et al. The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome. Archives of physiology and

70
  • 2022;128(1):37-42, Doi: https://doi.org/10.1080/13813455.2019.1662450 .
  • [28] Almenning I, Rieber-Mohn A, Lundgren KM, Shetelig Løvvik T, Garnaes KK, Moholdt T. Effects of high intensity interval training and strength training on metabolic, cardiovascular and hormonal outcomes in women with polycystic ovary syndrome: a pilot study. Plos one. 2015;10(9):e0138793, Doi: https://doi.org/10.1371/journal.pone.0138793.
  • [29] Kong Z, Sun S, Liu M, Shi Q. Short-term high-intensity interval training on body composition and blood glucose in overweight and obese young women. Journal of diabetes research. 2016;2016, Doi:https://doi.org/10.1155/2016/4073618.
  • [30] Shiravand F, Valipour V, Abbasi M. The effect of 8 weeks of HICT training on serum levels of catalase, malondialdehyde and maximal oxygen consumption in breast cancer survivors: Randomized clinical trial. KAUMS Journal (FEYZ). 2019;23(4):398-406, Doi: http://feyz.kaums.ac.ir/article-1-3844-en.html.
  • [31] Sun Q, Cornelis MC, Manson JE, Hu FB. Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the US. Diabetes. 2013;62(1):49-55, Doi: https://doi.org/10.2337/db12-0372 .
  • [32] Klika B, Jordan C. High-intensity circuit training using body weight: Maximum results with minimal investment. ACSM's Health & Fitness Journal. 2013;17(3):8-13, Doi: 1249/FIT.0b013e31828cb1e8
  • [33] Borg G. Borg's perceived exertion and pain scales: Human kinetics; 1998, Doi: https://psycnet.apa.org/record/1998-07179-000.
  • [34] Haidari F, Shayesteh F, Mohammad-Shahi M, Jalali M-T, Ahmadi-Angali K. Olive leaf extract supplementation combined with calorie-restricted diet on reducing body weight and fat mass in obese women: result of a randomized control trial. Clinical Nutrition Research. 2021;10(4):314, Doi: https://doi.org/10.7762/cnr.2021.10.4.314.
  • [35] Zaki M, Hussein J, Ibrahim AM, Youness ER. Circulating plasma free fatty acids, insulin resistance and metabolic markers in obese women. Biomedical and Pharmacology Journal. 2020;13(4):1595-600, Doi: https://dx.doi.org/10.13005/bpj/2034.
  • [36] Jafari-Vayghan H, Tarighat-Esfanjani A, Jafarabadi MA, Ebrahimi-Mameghani M, Ghadimi SS, Lalezadeh Z. Association between dietary patterns and serum leptin-to-adiponectin ratio in apparently healthy adults. Journal of the American College of Nutrition. 2015;34(1):49-55, Doi: https://doi.org/10.1080/07315724.2014.880389.
  • [37] Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J-i, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and biophysical research communications. 1999;257(1):79-83, Doi: https://doi.org/10.1006/bbrc.1999.0255.
  • [38] Scoditti E, Massaro M, Carluccio MA, Pellegrino M, Wabitsch M, Calabriso N, et al. Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes. PLoS One. 2015;10(6):e0128218, Doi: https://doi.org/10.1371/journal.pone.0128218.
  • [39] Jahandideh AA, Rohani H, Rajabi H, Shariatzade Joneidi M. Effect of 8-weeks of Combined Exercise Training on Plasma Leptin and Adiponectin levels in Obese Boys. Journal of Applied Health Studies in Sport Physiology. 2021;8(2):25-33, Doi: https://doi.org/10.22049/jahssp.2021.27330.1372.
  • [40] Rezaee Shirazi R. Effects of 12 weeks high intensity interval training on plasma Adiponectin, Leptin and insulin resistance in obese males with non-alcoholic fatty liver. Metabolism and Exercise. 2015;5(1):23-34, Doi: https://jme.guilan.ac.ir/article_1692_en.html.
  • [41] Shamsi M, Rahimi MR. The Effect of Eight Weeks of Resistance Training with Green Tea Extract Supplement On Serum Levels of Adiponectin and Pentraxin-3 In Obese Men. Journal of Applied Health Studies in Sport Physiology. 2021;8(2):94-101, Doi: https://dx.doi.org/10.22049/jahssp.2022.27526.1411.
  • [42] García-Hermoso A, Ceballos-Ceballos R, Poblete-Aro C, Hackney A, Mota J, Ramírez-Vélez R. Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials. International journal of obesity. 2017;41(4):475-82, Doi: https://doi.org/10.1038/ijo.2016.230.
  • [43] Kishali NF. Serum leptin level in healthy sedentary young men after a short-term exercise. African Journal of Pharmacy and Pharmacology. 2011;5(4):522-6, Doi: 5897/AJPP11.096.
  • [44] Siersbæk R, Nielsen R, Mandrup S. Transcriptional networks and chromatin remodeling controlling adipogenesis. Trends in Endocrinology & Metabolism. 2012;23(2):56-64, Doi: https://doi.org/10.1016/j.tem.2011.10.001.
  • [45] Bouter KE, van Raalte DH, Groen AK, Nieuwdorp M. Role of the gut microbiome in the pathogenesis of obesity and obesity-related metabolic dysfunction. Gastroenterology. 2017;152(7):1671-8, Doi: https://doi.org/10.1053/j.gastro.2016.12.048.
  • [46] De Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, et al. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PloS one. 2013;8(3):e57622, Doi: https://doi.org/10.22038/ijogi.2018.12245.
  • [47]Soriguer F, Almaraz M, Ruiz-de-Adana M, Esteva I, Linares F, García-Almeida J, et al. Incidence of obesity is lower in persons who consume olive oil. European journal of clinical nutrition. 2009;63(11):1371-, Doi: https://doi.org/10.1038/ejcn.2009.65.
  • [48] Park S, Choi Y, Um S-J, Yoon SK, Park T. Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice. Journal of hepatology. 2011;54(5):984-93, Doi: https://doi.org/10.1016/j.jhep.2010.08.019.
  • [49] Araki R, Fujie K, Yuine N, Watabe Y, Nakata Y, Suzuki H, et al. Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial. Nutrition Research. 2019;67:60-6, Doi: https://doi.org/10.1016/j.nutres.2019.05.003.
  • [50] Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. Journal of medicinal food. 2012;15(7):605-10, Doi: https://doi.org/10.1089/jmf.2011.0243.

پژوهش در تغذیه ورزشی
دوره 3، شماره 1
فروردین 1403
صفحه 59-71

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سابقه مقاله

  • تاریخ دریافت: 17 بهمن 1403
  • تاریخ بازنگری: 27 بهمن 1403
  • تاریخ پذیرش: 29 بهمن 1403
  • تاریخ اولین انتشار: 29 بهمن 1403

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