نوع مقاله : مقاله اصیل
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد مریوان، مریوان، ایران.
2 گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد مریوان، مریوان، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Aim: The purpose of this study was to investigate the effect of Salvia officinalis extract on the serum levels of caspase 3 after a downhill running session.
Method: 12 healthy men (age: 24.38±2.75, weight: 75.57±5.48, BMI: 24.69±1.70) were randomly assigned to two groups of sage supplement and placebo in a crossover manner. Subjects consumed 100 mg capsules of sage extract (two per day) or placebo for two weeks. After 2 weeks, they performed one session of exercise on a treadmill with a negative slope on one day. The exercise protocol included one session of exercise with a negative slope of 12% at an intensity of 70% of maximum heart rate until voluntary fatigue (the average voluntary fatigue of the subjects was 30 minutes). Blood sampling was performed in two stages before and immediately after the exercise session.
Results: There was no significant difference in serum caspase 3 levels between the supplement group and the placebo group in the pre-test (p=0.134). The results of the Bonferroni post-hoc test showed that in the supplement group, the changes in caspase levels in the post-test compared to the pre-test were not statistically significant (p=0.650). In the placebo group, the levels of caspase 3 in the post-test compared to the pre-test were significantly higher (p=0.01).
Conclusion: The running downhill as eccentric contractions may lead to cell apoptosis through increasing caspase 3 levels, but short-term consumption of Salvia officinalis supplement is likely to inhibit exercise-induced cell death.
کلیدواژهها [English]
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