بررسی سطوح برخی شاخص‌های آنتی اکسیدانی و التهابی متعاقب مکمل‌سازی کوآنزیم -Q10 پس از وهله‌های حاد فعالیت هوازی وامانده‌ساز در جودوکاران مرد

نوع مقاله : مقاله اصیل

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، گروه حرکت شناسی و مدیریت ورزشی، دانشگاه تگزاس A&M، تگزاس، آمریکا.

2 دانشجوی کارشناسی ارشد، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران.

3 پژوهشگر پسادکتری، گروه فیزیولوزی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران.

چکیده

هدف: این مطالعه با هدف بررسی اثرات مکمل‌سازی کوتاه‌مدت با کوآنزیم Q10 (CoQ10) بر نشانگرهای استرس اکسیداتیو و التهاب، به‌ویژه سوپراکسید دیسموتاز (SOD)، مالون دی‌آلدئید (MDA) و اینترلوکین-6 (IL-6)، به دنبال ورزش هوازی وامانده‌ساز در ورزشکاران جودو انجام شد.

روش شناسی: 16 ورزشکار جودوی مرد در یک مطالعه تصادفی، دوسوکور، متقاطع در قالب دو شرایط مکمل Co-Q10 و دارونما شرکت کردند. شرکت‌کنندگان بعد از انجام وهله اول فعالیت هوازی وامانده‌ساز به مدت 30 روز مکمل CoQ10 را مصرف کردند سپس وهله دوم فعالیت وامانده ساز را انجام دادند.. نمونه‌های خون قبل از ورزش، بلافاصله و 24 ساعت پس از ورزش در طول دو وهله فعالیت جهت سنجش سطوح SOD، MDA و IL-6 جمع آوری شد. این نشانگرها با استفاده از روش ایمونوسوربنت متصل به آنزیم (ELISA) و تکنیک های اسپکتروفتومتری آنالیز شدند.

یافته ها: مکمل سازی با CoQ10 به طور قابل توجهی سطوح SOD را پس از 30روز مکمل‌سازی در مقایسه با گروه دارونما افزایش داد (05/0>p). سطوح MDA و IL-6 به طور قابل توجهی در طول دوره ریکاوری پس از مکمل CoQ10 کاهش یافت (05/0>p). این یافته‌ها نشان می دهد که CoQ10 به طور موثر دفاع آنتی اکسیدانی را افزایش داده و پراکسیداسیون لیپیدی و التهاب ناشی از تمرین هوازی وامانده را کاهش می دهد.

نتیجه گیری: مکمل‌سازی CoQ10 استرس اکسیداتیو و پاسخ‌های التهابی را در ورزشکاران جودو پس از فعالیت هوازی وامانده‌ساز بهبود می‌بخشد. CoQ10 ممکن است یک استراتژی تغذیه‌ای موثر برای افزایش ریکاوری و کاهش آسیب سلولی ناشی از ورزش در ورزش‌های با شدت بالا باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Investigation of the Levels of Some Antioxidant and Inflammatory Markers Following Supplementation of CoenzymeQ10 after Acute Bouts of Exhausting Aerobic Exercise in Male Judo Athletes

نویسندگان [English]

  • Shadi Golpasandi 1
  • Mobina Khosravi 2
  • Hadi Golpasandi 3
1 PhD student in Exercise Physiology, Department of Kinesiology and Sport Management, Texas A&M University, Texas, USA.
2 Masters student, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
3 Postdoctoral researcher, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
چکیده [English]

Aim: This study aimed to investigate the effects of short-term supplementation with coenzyme Q10 (CoQ10) on markers of oxidative stress and inflammation, specifically superoxide dismutase (SOD), malondialdehyde (MDA), and interleukin-6 (IL-6), following exhaustive aerobic exercise in judo athletes.

Method: Sixteen male judo athletes participated in a randomized, double-blind, crossover study in which they received CoQ10 or placebo. Participants received CoQ10 supplementation for 30 days after completing a first bout of exhaustive aerobic exercise, then completed a second bout of exhaustive exercise. Blood samples were collected before exercise, immediately, and 24 hours after exercise during the two bouts to measure levels of SOD, MDA, and IL-6. These markers were analyzed using enzyme-linked immunosorbent assay (ELISA) and spectrophotometric techniques.

Results: CoQ10 supplementation significantly increased SOD levels after 30 days of supplementation compared to the placebo group (p<0.05). MDA and IL-6 levels were significantly reduced during the recovery period after CoQ10 supplementation (p<0.05). These findings suggest that CoQ10 effectively enhances antioxidant defences and reduces lipid peroxidation and inflammation induced by exhaustive aerobic exercise.

Conclusion: CoQ10 supplementation improves oxidative stress and inflammatory responses in judo athletes after exhaustive aerobic exercise. CoQ10 may be an effective nutritional strategy to enhance recovery and reduce exercise-induced cellular damage in high-intensity sports

کلیدواژه‌ها [English]

  • Coenzyme Q10
  • oxidative stress
  • exhausting aerobic exercise
  • judo

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سابقه مقاله

  • تاریخ دریافت: 13 آذر 1403
  • تاریخ بازنگری: 01 دی 1403
  • تاریخ پذیرش: 03 دی 1403
  • تاریخ اولین انتشار: 03 دی 1403

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