تاثیر کوتاه مدت مکمل HMB بر غلظت هورمون‌های رشد و تستوسترون به دنبال فعالیت مقاومتی در ورزشکاران

نوع مقاله : مقاله اصیل

نویسندگان

1 دانشیار فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران

2 کارشناس ارشد فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران

10.34785/J019.2023.006

چکیده

هدف: در پژوهش حاضر تاثیر مصرف مکمل HMB بر غلظت هورمونهای رشد و تستوسترون بدنبال فعالیت مقاومتی در ورزشکاران مورد بررسی قرار گرفت. روش پژوهش: در یک مطالعه دو سوکور، تصادفی، و کنترل شده با دارونما10 دانشجوی پسرورزشکار با میانگین سنی به طور تصادفی انتخاب و به مدت یک هفته مکمل HMB یا دارونما به میزان 3 گرم در روز (3 دوز 1 گرمی) مصرف کردند. سپس، یک هفته فاصله جهت پاکسازی بین دوره‌های بارگیری لحاظ شد. آزمودنی‌ها پس از یک هفته (مصرف مکمل یا دارونما) در فعالیت مقاومتی که شامل 3 ست با 85 درصد یک تکرار بیشینه با دو دقیقه استراحت بین ستها و حرکات شرکت کردند. بعد از یک هفته استراحت، آزمودنی‌ها فراخوانده شدند و با شیوه متقاطع با تغییر مکمل و دارونمای آنها به مدت یک هفته دیگر با همان شرایط قبلی به مصرف مکمل و دارونما پرداختند. سپس در فعالیت مقاومتی شرکت کرده و نمونه گیری خون از آنها بعمل آمد. نمونه‌های خون جهت اندازه‌گیری غلظت هورمونهای رشد و تستوسترون به روش الایزا به آزمایشگاه انتقال داده شد. یافته ها: یافته‌های این پژوهش با استفاده از آزمون آنالیز واریانس با اندازه‌گیری مکرر نشان داد که مصرف مکمل HMB به مدت یک هفته سبب افزایش معنی‌دار سطح تستوسترون در مردان تمرین کرده پس از فعالیت مقاومتی شده است (05/0p≤)؛ اما تاثیر معنیداری بر غلظت هورمون GH نداشت (05/0 p>). نتیجه‌گیری: با توجه یافته‌ها به نظر می‌رسد که مصرف کوتاه مدت HMB می‌تواند ترشح هورمون‌ آنابولیکی تستوسترون را پس از فعالیت مقاومتی در ورزشکاران افرایش دهد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of short-term HMB supplement on Growth hormone and Testosterone concentration after resistance exercise in the athletes

نویسندگان [English]

  • Mohammad Rahman Rahimi 1
  • Shahram Parsarad 2
1 Associate‌‌ Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
2 Master of exercise physiology, Department of Exercise Physiology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
چکیده [English]

Introduction: The aim of this study was to determine the effect of HMB supplement on the growth hormone and testosterone concentration following resistance exercise. Method: In a double-blind, randomized and placebo-controlled study, 10 college athletes with age (22±1.32), weight (45.76±9.13), BMI (23.7±1.99) and body fat percent (12.50±4.08) were randomly selected and ingested HMB (3 gr per day) and placebo (3 gr per day) for one week. Then, A washout period of one week was set between supplementation periods. After one week of supplementation period, subjects performed resistance exercise included 3 sets of bench press, lat pull down, leg extension, leg curl, biceps curl, triceps curl and shoulder press with 85% of 1RM and 2 min rest intervals between sets and exercises. Before and after resistance exercise blood samples were taken. After a week rest, subjects recalled, then supplement and placebo changed for each subject . They performed the same resistance exercise as previous session. After completion of resistance exercise blood samples were collected for measuring growth and testosterone hormones by ELISA method. Results: The results using ANOVA with repeated measures showed that one week ingestion of HMB significantly increased TS levels, but didn’t affect GH hormone secretion. Conclusion: Based on the results, it seems that short-term ingestion of HMB can induceded increase in secretion of TS anabolic hormones after resistance exercise in athletes.

کلیدواژه‌ها [English]

  • HMB supplement
  • Growth hormone
  • Testosterone hormone
  1. Nissen S, Sharp RL, Panton L, Vukovich M, Trappe S, Fuller JC, Jr. β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Humans Is Safe and May Decrease Cardiovascular Risk Factors. The Journal of Nutrition. 2000;130(8):1937-45.
  2. Nissen S, Sharp R, Ray M, Rathmacher J, Rice D, Fuller Jr J, et al. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. Journal of Applied Physiology. 1996.
  3. Slater GJ, Jenkins D. β-Hydroxy-β-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Medicine. 2000;30(2):105-16.
  4. Zanchi NE, Gerlinger-Romero F, Guimaraes-Ferreira L, de Siqueira Filho MA, Felitti V, Lira FS, et al. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino acids. 2011;40(4):1015-25.
  5. Fuller JC, Sharp RL, Angus HF, Baier SM, Rathmacher JA. Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt. British Journal of Nutrition. 2011;105(3):367-72.
  6. Fuller JC, Sharp RL, Angus HF, Khoo PY, Rathmacher JA. Comparison of availability and plasma clearance rates of β-hydroxy-β-methylbutyrate delivery in the free acid and calcium salt forms. British Journal of Nutrition. 2015;114(9):1403-9.
  7. Gerlinger-Romero F, Guimarães-Ferreira L, Giannocco G, Nunes MT. Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats. Growth Hormone & IGF Research. 2011;21(2):57-62.
  8. Pakzad Hasanlou F, Vakili J, Nikokheslat S. The Effect of Traditional Resistance Training and with Blood Flow Restriction on Anabolic and Catabolic Hormonal Markers in Active Males. Journal of Applied Health Studies in Sport Physiology. 2020;7(1):45-54.
  9. Rahimi R, Qaderi M, Faraji H, Boroujerdi SS. Effects of very short rest periods on hormonal responses to resistance exercise in men. The Journal of Strength & Conditioning Research. 2010;24(7):1851-9.
  10. Rahman Rahimi HF, Vatani DS, Qaderi M. Creatine supplementation alters the hormonal response to resistance exercise. Kinesiology. 2010;42(1):28-35.
  11. Rahimi MR, Khodamoradi M, Falah F. Effects of caffeine consumption before resistance exercise on blood levels of testosterone and growth hormones in male athletes. Koomesh journal. 1398;21(4):679-85.
  12. Amirsasan R, Vakili J, Shakib A, Armanfar M. Comparing the Effect of one-week supplementation of Citrulline-malate, L-arginine and their combination on growth hormone concentration and metabolic responses in male wrestlers. Journal of Applied Health Studies in Sport Physiology. 2018;5(1):1-9.
  13. Ravasi AA, Mirza Hoseini O, Armanfar M, Ghodsmirheidari F. Effect of branched-chain amino acids supplementation with two different amounts on anabolic hormone response after heavy resistance activity in Paralympic weightlifters. Journal of Applied Health Studies in Sport Physiology. 2018;5(1):62-8.
  14. Portal S, Zadik Z, Rabinowitz J, Pilz-Burstein R, Adler-Portal D, Meckel Y, et al. The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled study. European journal of applied physiology. 2011;111(9):2261-9.
  15. Zhao L, Mohammad M. Testosterone and cortisol responses to ß‐hydroxy ß‐methylbutryate consumption and exercise: A meta‐analysis. Food Science & Nutrition. 2022.
  16. Townsend JR, Hoffman JR, Gonzalez AM, Jajtner AR, Boone CH, Robinson EH, et al. Effects of β-hydroxy-β-methylbutyrate free acid ingestion and resistance exercise on the acute endocrine response. International journal of endocrinology. 2015;2015.
  17. Wilson JM, Lowery RP, Joy JM, Walters JA, Baier SM, Fuller JC, et al. β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men. British Journal of Nutrition. 2013;110(03):538-44.
  18. Rahimi MR, Shoker-Nejad H. Effects of β-Hydroxy-β-Methylbutyrate Supplementation on IL-4, IL-10 and TGF-β1 during Resistance Exercise in Athletes. Research in Exercise Nutrition. 2022;1(1):40-21.
  19. Hooper DR, Kraemer WJ, Focht BC, Volek JS, DuPont WH, Caldwell LK, Maresh CM. Endocrinological roles for testosterone in resistance exercise responses and adaptations. Sports Medicine. 2017;47(9):1709-20.
  20. McPhaul MJ, Young M. Complexities of androgen action. Journal of the American Academy of dermatology. 2001;45(3):S87-S94.
  21. Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports medicine. 2005;35(4):339-61.
  22. Donike M. Detection of exogenous testosterone. Leistung und Gesundheit, Kongressbd. 1983.
  23. Assad MR, Zoghi R, Fashi M. The Effect of 8 Weeks Resistance Training with HMB Supplementary Product on Changes in Growth Hormone and Testosteron Over Un athlete Males. Alborz University Medical Journal. 2016;5(3):187-93.
  24. Arazi H, Rohani H, Ghiasi A, Keikanloo NA. Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones. Revista Brasileira de Medicina do Esporte. 2015;21:386-9.
  25. Faramarzi M, Ghasempour HR, Banitalebi E, Ghafoorian M, Ghatre-Samani k. Effects of β -hydroxy- β -methylbutyrate on kidney parameters and body composition in untrained males after 8 weeks combination resistance training. Journal of Shahrekord Uuniversity of Medical Sciences. 2012;13(6):38-46.
  26. Townsend JR, Hoffman JR, Gonzalez AM, Jajtner AR, Boone CH, Robinson EH, et al. Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response. International journal of endocrinology. 2015;2015:856708.
  27. Kraemer WJ, Hatfield DL, Volek JS, Fragala MS, Vingren JL, Anderson JM, et al. Effects of amino acids supplement on physiological adaptations to resistance training. Medicine & Science in Sports & Exercise. 2009;41(5):1111-21.
دوره 1، شماره 2
شهریور 1401
صفحه 53-62
  • تاریخ دریافت: 18 اسفند 1401
  • تاریخ بازنگری: 27 فروردین 1402
  • تاریخ پذیرش: 27 فروردین 1402
  • تاریخ اولین انتشار: 27 فروردین 1402